BioThrax Dosage

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Restricted Distribution in US

[distributed directly to US Depts. of Defense and Health and Human Services]

Immunization

[pre-exposure, IM route]

Dose: 0.5 mL IM x1 at mo 0, 1, 6, 12, and 18 for 5 total doses; Info: for pts 18-65 yo w/ high risk of exposure to B. anthracis; give booster dose of 0.5 mL IM q12mo if continued risk; may give booster dose q3y in non-high risk pts

[pre-exposure, SC route]

Dose: 0.5 mL SC x1 on wk 0, 2, and 4, then at mo 6, 12, and 18 for 6 total doses; Info: for pts 18-65 yo w/ high risk of exposure to B. anthracis; give booster dose of 0.5 mL SC q12mo if continued risk

[post-exposure]

Dose: 0.5 mL SC/IM x1 on wk 0, 2, and 4 for 3 total doses; Info: for pts 18-65 yo; SC preferred to IM; use in combo w/ antimicrobial post-exposure prophylaxis; may admin. to pregnant pts, nursing mothers, pts 66 yo or older in emergency situations

[*post-exposure, dose-sparing regimens]

Dose: 0.5 mL SC/IM x1 on wk 0 and 2 for 2 total doses; Alt: 0.5 mL SC/IM x1 on wk 0 and 4 for 2 total doses; 0.25 mL SC/IM x1 on wk 0, 2, and 4 for 3 total doses; Info: for emergency situations when vaccine supply insufficient; SC preferred to IM; use in combo w/ antimicrobial post-exposure prophylaxis

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .