Bosutinib Dosage
Generic name: bosutinib
Brand name: Bosulif
Dosage form: oral tablet (100 mg; 400 mg; 500 mg)
Drug class: BCR-ABL tyrosine kinase inhibitors
Adult Dosing
Dosage forms: TAB: 100 mg, 400 mg, 500 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
Ph-positive CML
- [chronic phase, newly diagnosed dz]
- Dose: 400 mg PO qd; Info: may incr. dose to 600 mg PO qd; give w/ food; do not cut/crush/chew tab
- [chronic phase, resistant or intolerant dz]
- Dose: 500 mg PO qd; Info: may incr. dose to 600 mg PO qd; give w/ food; do not cut/crush/chew tab
- [accelerated phase or blast phase, resistant or intolerant dz]
- Dose: 500 mg PO qd; Info: may incr. dose to 600 mg PO qd; give w/ food; do not cut/crush/chew tab
Renal dosing
- [newly diagnosed dz]
- CrCl 30-50: 300 mg qd; CrCl <30: 200 mg qd
- HD/PD: not defined
- [resistant or intolerant dz]
- CrCl 30-50: 400 mg qd; CrCl <30: 300 mg qd
- HD/PD: not defined
Hepatic dosing
- [adjust dose amount]
- Child-Pugh Class A, B, or C: 200 mg qd
SRC: NLM .