Brukinsa Dosage

Generic name: zanubrutinib
Drug class: BTK inhibitors

Medically reviewed by  A Ras MD.

Adult Dosing

Dosage forms:  CAP: 80 mg

Special Note

[uses, dosing may vary]

Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments

Mantle cell lymphoma, relapsed or refractory

[160 mg PO bid]

Alt: 320 mg PO qd; Info: consider holding tx 3-7 days before and after surgery; consider HSV and PCP prophylaxis

Waldenstrom macroglobulinemia

[160 mg PO bid]

Alt: 320 mg PO qd; Info: consider holding tx 3-7 days before and after surgery; consider HSV and PCP prophylaxis

Marginal zone lymphoma, relapsed or refractory

[160 mg PO bid]

Alt: 320 mg PO qd; Info: for pts who have received at least one anti-CD20-based tx; consider holding tx 3-7 days before and after surgery; consider HSV and PCP prophylaxis

Renal dosing

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined, caution advised

Hepatic dosing

[adjust dose amount]

Child-Pugh Class C: 80 mg bid