Celontin Dosage

Generic name: methsuximide
Drug class: Succinimide anticonvulsants

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 300 mg

Absence seizures, refractory

[300-1200 mg PO qd]

Start: 300 mg PO qd x1wk, may incr. by 300 mg/day qwk; Max: 1200 mg/day; Info: adjust dose based on tx response and serum levels; may divide total daily dose based on tolerability and safety; taper dose gradually to D/C

Renal dosing

renal impairment: not defined, caution advised; Info: metabolite accumulation possible

HD/PD: not defined, caution advised

Hepatic dosing

[not defined]

hepatic dz: caution advised

Recommended Pediatric Dosing

Dosage forms:  CAP: 300 mg

Absence seizures, refractory

[300-1200 mg PO qd]

Start: 300 mg PO qd x1wk, may incr. by 300 mg/day qwk; Max: 1200 mg/day; Info: adjust dose based on tx response and serum levels; may divide total daily dose based on tolerability and safety; taper dose gradually to D/C

Renal dosing

renal impairment: not defined, caution advised; Info: metabolite accumulation possible

HD/PD: not defined, caution advised

Hepatic dosing

[not defined]

hepatic dz: caution advised

SRC: NLM .