Cinvanti Dosage
Generic name: Aprepitant Injection
Drug class: NK1 receptor antagonists
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Special Note
- [dosing clarification]
- Info: for PO aprepitant dosing see aprepitant or Emend; for IV fosaprepitant dosing see fosaprepitant or Emend Injection
Nausea/vomiting prevention, chemo-related
- [highly-emetogenic chemo]
- Dose: 130 mg IV x1 on day 1; Start: 30min before chemo; Info: give w/ corticosteroid and 5-HT3 antagonist
- [moderately-emetogenic chemo, 1-day regimen]
- Dose: 130 mg IV x1 on day 1; Start: 30min before chemo; Info: give w/ corticosteroid and 5-HT3 antagonist
- [moderately-emetogenic chemo, 3-day regimen]
- Dose: 100 mg IV x1 on day 1, then oral aprepitant 80 mg PO qd on days 2-3; Start: 30min before chemo; Info: give w/ corticosteroid and 5-HT3 antagonist
Renal dosing
- renal impairment: no adjustment needed.
- HD: no adjustment; no supplement; PD: not defined
Hepatic dosing
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
SRC: NLM .