Cobicistat Dosage

Generic name: cobicistat
Brand name: Tybost
Dosage form: oral tablet (150 mg)
Drug class: Antiviral boosters

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 150 mg

Antiretroviral boosting

[w/ atazanavir 300 mg PO qd]

Dose: 150 mg PO qd; Info: give w/ food

[w/ darunavir 800 mg PO qd]

Dose: 150 mg PO qd; Info: for tx-naive pts or tx-experienced pts w/o darunavir resistance-assoc. substitutions; give w/ food

Renal dosing

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Recommended Peds Dosing

Dosage forms:  TAB: 150 mg

Antiretroviral boosting

[w/ atazanavir 300 mg PO qd]

Dose: 150 mg PO qd; Info: for pts >35 kg; give w/ food

[w/ darunavir 800 mg PO qd]

Dose: 150 mg PO qd; Info: for tx-naive pts >40 kg or tx-experienced pts w/o darunavir resistance-assoc. substitutions >40 kg; give w/ food

Renal dosing

[see below]

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[see below]

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

SRC: NLM .