Dactinomycin Dosage

Generic name: dactinomycin
Brand name: Cosmegen
Drug class: Antibiotics / antineoplastics

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ

Wilms tumor

[45 mcg/kg/dose IV q3-6wk for up to 26wk]

Info: part of multi-drug chemo regimen

Rhabdomyosarcoma

[15 mcg/kg/dose IV qd x5 days q3-9wk for up to 112wk]

Info: part of multi-drug chemo regimen

Ewing sarcoma

[1250 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x17 cycles]

Info: part of multi-drug chemo regimen

Gestational trophoblastic neoplasia

[low-risk and non-metastatic dz, monotherapy]

Dose: 12 mcg/kg/dose IV qd x5 days

[high-risk metastatic dz, combo tx]

Dose: 500 mcg IV x1 on days 1-2 of 14-day cycle for up to 4 cycles

Solid malignancy, locally recurrent or locoregional

[lower extremity or pelvis]

Dose: 50 mcg/kg/dose via regional perfusion x1; Info: for adjunctive or palliative tx; use w/ melphalan

[upper extremity]

Dose: 35 mcg/kg/dose via regional perfusion x1; Info: for adjunctive or palliative tx; use w/ melphalan

Nonseminomatous testicular CA, metastatic

[1000 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x4 cycles]

Info: part of multi-drug chemo regimen

Osteosarcoma

[600 mcg/m^2/dose IV x1 on days 1-3 of tx wk 15, 31, 34, 39, and 42]

Info: part of multi-drug chemo regimen

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  INJ

Wilms tumor

[45 mcg/kg/dose IV q3-6wk for up to 26wk]

Info: part of multi-drug chemo regimen

Rhabdomyosarcoma

[15 mcg/kg/dose IV qd x5 days q3-9wk for up to 112wk]

Info: part of multi-drug chemo regimen

Ewing sarcoma

[1250 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x17 cycles]

Info: part of multi-drug chemo regimen

Gestational trophoblastic neoplasia

[low-risk and non-metastatic dz, monotherapy, postmenarchal pts]

Dose: 12 mcg/kg/dose IV qd x5 days

[high-risk metastatic dz, combo tx, postmenarchal pts]

Dose: 500 mcg IV x1 on days 1-2 of 14-day cycle for up to 4 cycles

Nonseminomatous testicular CA, metastatic

[1000 mcg/m^2/dose IV x1 on day 1 of 21-day cycle x4 cycles]

Info: part of multi-drug chemo regimen

Osteosarcoma

[600 mcg/m^2/dose IV x1 on days 1-3 of tx wk 15, 31, 34, 39, and 42]

Info: part of multi-drug chemo regimen

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

 

 

 

SRC: NLM .