Encorafenib Dosage

Generic name: encorafenib
Brand name: Braftovi
Drug class: Multikinase inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 75 mg

Melanoma, unresectable or metastatic

[450 mg PO qd]

Info: for pts w/ BRAF V600E or V600K mutation; use w/ binimetinib; decr. dose to max 300 mg PO qd if binimetinib withheld

Colorectal CA, metastatic

[300 mg PO qd]

Info: for pts w/ BRAF V600E mutation; use w/ cetuximab

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A: no adjustment; Child-Pugh Class B or C: not defined