Jentadueto XR Dosage
Generic name: linagliptin and metformin
Brand names: Jentadueto, Jentadueto XR
Drug class: Antidiabetic combinations
Recommended Adult Dosing
Dosage forms: TAB: 2.5 mg IR/1000 mg ER, 5 mg IR/1000 mg ER
Diabetes mellitus, type 2
- [conversion from linagliptin]
- Dose: 1-2 tabs PO qd; Start: 5 mg/1000 mg PO qd; Max: 5 mg/2000 mg/day; Info: give w/ meal; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn
- [conversion from metformin]
- Dose: 1-2 tabs PO qd; Start: linagliptin 5 mg PO qd w/ current total daily metformin dose PO qd; Max: 5 mg/2000 mg/day; Info: give w/ meal; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn
- [conversion from linagliptin plus metformin]
- Dose: 1-2 tabs PO qd; Start: linagliptin 5 mg PO qd w/ current total daily metformin dose PO qd; Max: 5 mg/2000 mg/day; Info: give w/ meal; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn
Renal dosing
- eGFR 30-44: avoid tx initiation; eGFR <30: contraindicated; Info: weigh risk/benefit if eGFR 30-44 during tx
- HD/PD: avoid use
Hepatic dosing
- hepatic impairment: avoid use
SRC: NLM .