Lyrica Dosage

Generic name: pregabalin
Brand names: Lyrica, Lyrica CR
Drug class: Gamma-aminobutyric acid analogs

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  CAP: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg; SOL: 20 mg per mL

Neuropathic pain, diabetic

[50-100 mg PO tid]

Start: 50 mg PO tid, may incr. to 100 mg PO tid w/in 1wk; Max: 600 mg/day; Info: doses >300 mg/day rarely more effective, may incr. ADR risk; taper dose over >1wk to D/C

Neuropathic pain, spinal cord injury-assoc.

[75-300 mg PO bid]

Start: 75 mg PO bid, may incr. to 150 mg PO bid w/in 1wk, then may incr. to 300 mg PO bid after another 2-3wk; Max: 600 mg/day; Info: taper dose over >1wk to D/C

Post-herpetic neuralgia

[150-300 mg/day PO divided bid-tid]

Start: 150 mg/day PO divided bid-tid, may incr. to 300 mg/day PO divided bid-tid w/in 1wk, then may incr. to 600 mg/day PO divided bid-tid after another 2-4wk; Max: 600 mg/day; Info: taper dose over >1wk to D/C

Partial seizures, adjunct tx

[150-600 mg/day PO divided bid-tid]

Start: 150 mg/day PO divided bid-tid; Max: 600 mg/day; Info: taper dose over >1wk to D/C

Fibromyalgia

[150-225 mg PO bid]

Start: 75 mg PO bid, may incr. to 150 mg PO bid w/in 1wk; Max: 450 mg/day; Info: taper dose over >1wk to D/C

Renal dosing

[if usual dose 150 mg/day]

CrCl 30-60: 75 mg/day divided bid-tid; CrCl 15-29: 25-50 mg/day divided qd-bid; CrCl <15: 25 mg qd

HD: 25 mg qd; give 25-50 mg as supplement after dialysis if next maint. dose not due right after dialysis; PD: not defined

[if usual dose 300 mg/day]

CrCl 30-60: 150 mg/day divided bid-tid; CrCl 15-29: 75 mg/day divided qd-bid; CrCl <15: 25-50 mg qd

HD: 25-50 mg qd; give 50-75 mg as supplement after dialysis if next maint. dose not due right after dialysis; PD: not defined

[if usual dose 450 mg/day]

CrCl 30-60: 225 mg/day divided bid-tid; CrCl 15-29: 100-150 mg/day divided qd-bid; CrCl <15: 50-75 mg qd

HD: 50-75 mg qd; give 75-100 mg as supplement after dialysis if next maint. dose not due right after dialysis; PD: not defined

[if usual dose 600 mg/day]

CrCl 30-60: 300 mg/day divided bid-tid; CrCl 15-29: 150 mg/day divided qd-bid; CrCl <15: 75 mg qd

HD: 75 mg qd; give 100-150 mg as supplement after dialysis if next maint. dose not due right after dialysis; PD: not defined

Hepatic dosing

[no adjustment]

Recommended Peds Dosing

Dosage forms:  CAP: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg; SOL: 20 mg per mL

Partial seizures, adjunct tx

[1 mo-3 yo, <30 kg]

Dose: 3.5-14 mg/kg/day PO divided tid; Start: 3.5 mg/kg/day PO divided tid, may incr. dose qwk; Max: 14 mg/kg/day; Info: taper dose over >1wk to D/C

[1 mo-3 yo, >30 kg]

Dose: 2.5-10 mg/kg/day PO divided bid-tid; Start: 2.5 mg/kg/day PO divided bid-tid, may incr. dose qwk; Max: 10 mg/kg/day up to 600 mg/day; Info: taper dose over >1wk to D/C

[4 yo and older, <30 kg]

Dose: 3.5-14 mg/kg/day PO divided bid-tid; Start: 3.5 mg/kg/day PO divided bid-tid, may incr. dose qwk; Max: 14 mg/kg/day; Info: taper dose over >1wk to D/C

[4 yo and older, >30 kg]

Dose: 2.5-10 mg/kg/day PO divided bid-tid; Start: 2.5 mg/kg/day PO divided bid-tid, may incr. dose qwk; Max: 10 mg/kg/day up to 600 mg/day; Info: taper dose over >1wk to D/C

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance

SRC: NLM .