Matulane Dosage

Generic name: procarbazine
Drug class: Miscellaneous antineoplastics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Hodgkin lymphoma, advanced

[monotherapy]

Dose: 1-2 mg/kg/day PO divided qd-bid; Start: 2-4 mg/kg/day PO divided qd-bid x7 days, then 4-6 mg/kg/day PO divided qd-bid until maximum response, then 1-2 mg/kg/day PO divided qd-bid

[combo tx]

Dose: 100 mg/m^2/dose PO qd on days 1-14 of each cycle

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised

Recommended Peds Dosing

Dosage forms:  CAP: 50 mg

Hodgkin lymphoma, advanced

[initial tx]

Dose: 100 mg/m^2/dose PO qd; Start: 50 mg/m^2/dose PO qd x7 days

[maintenance tx]

Dose: 50 mg/m^2/dose PO qd

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .