Mavenclad Dosage

Generic name: cladribine (oral)
Drug class: Antimetabolites

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 10 mg

Multiple sclerosis, relapsing forms

[40-49.9 kg]

Dose: 40 mg/cycle PO divided qd x4 consecutive days, then 23-27 days later, give 40 mg/cycle PO divided qd x4 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

[50-59.9 kg]

Dose: 50 mg/cycle PO divided qd x4-5 consecutive days, then 23-27 days later, give 50 mg/cycle PO divided qd x4-5 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

[60-69.9 kg]

Dose: 60 mg/cycle PO divided qd x4-5 consecutive days, then 23-27 days later, give 60 mg/cycle PO divided qd x4-5 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

[70-79.9 kg]

Dose: 70 mg/cycle PO divided qd x4-5 consecutive days, then 23-27 days later, give 70 mg/cycle PO divided qd x4-5 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

[80-89.9 kg]

Dose: 80 mg/cycle PO divided qd x4-5 consecutive days, then 23-27 days later, give 70 mg/cycle PO divided qd x4-5 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

[90-99.9 kg]

Dose: 90 mg/cycle PO divided qd x5 consecutive days, then 23-27 days later, give 80 mg/cycle PO divided qd x4-5 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

[100-109.9 kg]

Dose: 100 mg/cycle PO divided qd x5 consecutive days, then 23-27 days later, give 90 mg/cycle PO divided qd x5 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

[>110 kg]

Dose: 100 mg/cycle PO divided qd x5 consecutive days, then 23-27 days later, give 100 mg/cycle PO divided qd x5 consecutive days; Max: 20 mg/day; Info: repeat for 2nd tx course, starting >43wk after 1st tx course completed

Renal dosing

CrCl <60: avoid use

HD/PD: not defined

Hepatic dosing

Child-Pugh Class B or C: avoid use

SRC: NLM .