Niraparib Dosage

Generic name: niraparib
Brand name: Zejula
Drug class: PARP inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 100 mg

Ovarian CA, maintenance tx

[first-line tx, <77 kg or Plt <150,000]

Dose: 200 mg PO qd; Start: w/in 12wk of last platinum-based tx; Info: for platinum-sensitive advanced epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap

[first-line tx, >77 kg and Plt >150,000]

Dose: 300 mg PO qd; Start: w/in 12wk of last platinum-based tx; Info: for platinum-sensitive advanced epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap

[recurrent dz]

Dose: 300 mg PO qd; Start: w/in 8wk of last platinum-based tx; Info: for platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap

Homologous recombination deficiency-positive ovarian CA, advanced

[300 mg PO qd]

Info: for pts w/ ovarian, fallopian tube, or primary peritoneal CA who have received at least 3 prior tx w/ genomic instability score (GIS) 42 or greater whose dz progressed >6mo after response to last platinum-based tx or w/ confirmed or suspected BRCA mutation; do not open cap

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

Hepatic dosing

bilirubin <1.5x ULN and any AST: no adjustment; bilirubin 1.5-3x ULN and any AST: start 200 mg qd; bilirubin >3x ULN and any AST: not defined

SRC: NLM .