Ocrelizumab Dosage

Recommended Adult Dosing

Dosage forms:  INJ

Multiple sclerosis, relapsing forms

[600 mg IV q6mo]

Start: 300 mg IV x1, then 300 mg IV x1 after 2wk, then 600 mg IV x1 at 6mo after 1st dose; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; premed w/ corticosteroid 30min before and antihistamine 30-60min before each infusion; consider premed w/ antipyretic

Multiple sclerosis, primary progressive forms

[600 mg IV q6mo]

Start: 300 mg IV x1, then 300 mg IV x1 after 2wk, then 600 mg IV x1 at 6mo after 1st dose; Info: premed w/ corticosteroid 30min before and antihistamine 30-60min before each infusion; consider premed w/ antipyretic

Renal dosing

mild impairment: no adjustment; mod-severe impairment: not defined

HD/PD: not defined

Hepatic dosing

mild impairment: no adjustment; mod-severe impairment: not defined