Ofloxacin Dosage

Generic name: ofloxacin (oral)
Brand names: Floxin, Floxin I.V.
Dosage form: oral tablet (200 mg; 300 mg; 400 mg)
Drug class: Quinolones

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 200 mg, 300 mg, 400 mg

Infections, bacterial

[200-400 mg PO q12h]

Info: dose, duration varies w/ infection type, severity

Prostatitis

[300 mg PO q12h x6wk]

UTI, complicated

[200 mg PO q12h x10 days]

UTI, uncomplicated

[200 mg PO q12h x3-7 days]

Info: for pts w/ no alternative tx options; give x3 days if cystitis; refer to IDSA guidelines

Leprosy (Hansen dz), multibacillary

[pts who cannot take clofazimine]

Dose: 400 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 12mo in refractory cases

[pts who cannot take rifampin]

Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases

Leprosy (Hansen dz), paucibacillary

[pts who cannot take rifampin]

Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases

typhoid fever

[400 mg PO bid x7-14 days]

Renal dosing

CrCl 20-50: give usual dose q24h; CrCl <20: give usual dose x1, then give 50% usual dose q24h

HD/PD: not defined

Hepatic dosing

[adjust dose amount]

cirrhosis: max 400 mg/24h

Recommended Peds Dosing

Dosage forms:  TAB: 200 mg, 300 mg, 400 mg

Leprosy (Hansen dz), multibacillary

[15 yo and older, pts who cannot take clofazimine]

Dose: 400 mg PO qd x12mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 12mo in refractory cases

[15 yo and older, pts who cannot take rifampin]

Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases

Leprosy (Hansen dz), paucibacillary

[15 yo and older, pts who cannot take rifampin]

Dose: 400 mg PO qd x24mo; Info: not 1st-line agent; part of multi-drug regimen; may continue tx beyond 24mo in refractory cases

Typhoid fever

[20 mg/kg/dose PO bid x10 days]

Max: 400 mg/dose

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance

 

SRC: NLM .