Orkambi Dosage

Generic name: ivacaftor and lumacaftor
Drug class: CFTR combinations

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 200 mg/125 mg

Cystic fibrosis

[2 tabs PO q12h]

Max: 800 mg/500 mg; Info: for pts w/ homozygous F508del-CFTR mutation; give w/ fat-containing food

Renal dosing

CrCl >31: no adjustment; CrCl <31: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

Child-Pugh Class B: 2 tabs qam and 1 tab qpm; Child-Pugh Class C: 1 tab no more frequently than q12h

SRC: NLM .