Pegasys Dosage

Recommended Adult Dosing

Dosage forms:  INJ (pre-filled syringe): 180 mcg per 0.5 mL; INJ (vial): 180 mcg per mL

Hepatitis B infection, chronic

[180 mcg SC qwk x48wk]

Info: see pkg insert for dose adjustments based on toxicities

Renal dosing

[see below]

CrCl <30: 135 mcg qwk; Info: see pkg insert for dose adjustments based on toxicities

HD: 135 mcg qwk; no supplement after dialysis; PD: not defined; Info: see pkg insert for dose adjustments based on toxicities

Hepatic dosing

[see below]

Child-Pugh Class B or C or autoimmune hepatitis: contraindicated

Recommended Peds Dosing

Dosage forms:  INJ (pre-filled syringe): 180 mcg per 0.5 mL; INJ (vial): 180 mcg per mL

Hepatitis B infection, chronic

[3 yo and older]

Dose: 180 mcg/1.73 m^2 SC qwk x48wk; Max: 180 mcg/dose; Info: see pkg insert for dose adjustments based on toxicities

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[see below]

Child-Pugh Class B or C or autoimmune hepatitis: contraindicated