Photofrin Dosage

Generic name: porfimer
Drug class: Malignancy photosensitizers

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Esophageal CA, palliative tx

[2 mg/kg/dose IV x1]

Info: to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >30 days, up to 3 courses total

Endobronchial non-small cell lung CA

[microinvasive dz]

Dose: 2 mg/kg/dose IV x1; Info: for pts ineligible for surgery or XRT; to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >30 days, up to 3 courses total

[palliative tx]

Dose: 2 mg/kg/dose IV x1; Info: to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >30 days, up to 3 courses total

Barrett esophagus dysplasia, high-grade

[2 mg/kg/dose IV x1]

Info: for pts ineligible for esophagectomy; to complete 2-step photodynamic tx (PDT) use laser light 40-50h post-injection, may repeat laser light 96-120h post-injection; may repeat 2-step PDT after >90 days, up to 3 courses total

Renal dosing

renal impairment: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .