Pimozide Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 1 mg, 2 mg
Tourette syndrome, severe
- [2-10 mg/day PO divided qd-bid]
- Start: 1-2 mg/day PO divided qd-bid, may incr. dose qod; Max: 0.2 mg/kg/day up to 10 mg/day; Info: perform CYP2D6 genotyping if doses >4 mg/day; in poor CYP2D6 metabolizers, may incr. dose q14 days up to max 4 mg/day; taper dose gradually to D/C; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
Renal dosing
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
Recommended Peds Dosing
- Dosage forms: TAB: 1 mg, 2 mg
Tourette syndrome, severe
- [12 yo and older]
- Dose: 1-10 mg/day PO divided qd-bid; Start: 0.05 mg/kg/dose PO qhs, may incr. dose q3 days; Max: 0.2 mg/kg/day up to 10 mg/day; Info: perform CYP2D6 genotyping if doses >0.05 mg/kg/day; in poor CYP2D6 metabolizers, may incr. dose q14 days up to max 0.05 mg/kg/day; taper dose gradually to D/C; D/C if ANC <1000; consider D/C if unexplained decr. in WBC
Renal dosing
- renal impairment: not defined, caution advised
- HD/PD: not defined, caution advised
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
SRC: NLM .