Premarin Intravenous Dosage

Generic name: conjugated estrogens (intravenous route)
Drug class: Estrogens

Medically reviewed by  A Ras MD.

 Recommended Adult Dosing

Dosage forms:  TAB: 0.3 mg, 0.45 mg, 0.625 mg, 0.9 mg, 1.25 mg; INJ: various

Vasomotor sx, mod-severe menopausal

[0.3-1.25 mg PO qd]

Start: 0.3 mg PO qd; Alt: cycle 25 days on, 5 days off; Info: add progestin x10-14 days/cycle if intact uterus; use lowest effective estrogen dose, shortest effective tx duration

Vulvovaginal atrophy, menopausal

[0.3-1.25 mg PO qd]

Start: 0.3 mg PO qd; Alt: cycle 25 days on, 5 days off; Info: add progestin x10-14 days/cycle if intact uterus; use lowest effective estrogen dose, shortest effective tx duration; not preferred if local sx only

Osteoporosis prevention, postmenopausal

[0.3-0.625 mg PO qd]

Start: 0.3 mg PO qd; Alt: cycle 25 days on, 5 days off; Info: add progestin x10-14 days/cycle if intact uterus; weigh estrogen tx risk/benefit

Hypoestrogenism

[assoc. w/ hypogonadism]

Dose: 0.3-1.25 mg PO qd; Info: cycle 21 days on, 7 days off; titrate to lowest effective maint. dose; add progestin x10-14 days/cycle if intact uterus; reassess tx need q3-6mo

[assoc. w/ oopherectomy or primary ovarian failure]

Dose: 1.25 mg PO qd; Info: cycle 21 days on, 7 days off; add progestin x10-14 days/cycle if intact uterus; reassess tx need q3-6mo

Metastatic breast CA, palliative tx

[10 mg PO tid for at least 3mo]

Advanced prostate CA, palliative tx

[1.25-2.5 mg PO tid]

Dysfunctional uterine bleeding

[25 mg IM/IV x1]

Info: may repeat dose in 6-12h; IV route preferred over IM route

Uremic bleeding

[0.6 mg/kg/dose IV qd x5 days]

Renal dosing

renal dz: not defined, caution advised

HD/PD: not defined, caution advised

Hepatic dosing

hepatic impairment: contraindicated

SRC: NLM .