Selexipag Dosage
Generic name: selexipag (oral/injection)
Brand names: Uptravi, Uptravi Titration Pack
Drug class: Agents for pulmonary hypertension
Recommended Adult Dosing
Dosage forms: TAB: 200 mcg, 400 mcg, 600 mcg, 800 mcg, 1000 mcg, 1200 mcg, 1400 mcg, 1600 mcg; INJ: 1800 mcg
Restricted Distribution in US
Pulmonary arterial HTN
- [200-1600 mcg PO bid]
- Start: 200 mcg PO bid, may incr. by 400 mcg/day PO qwk as tolerated; Max: 3200 mcg/day PO; 3600 mcg/day IV; Alt: 225-1800 mcg IV bid; Info: may use IV temporarily if unable to take PO; see pkg insert for PO/IV dose conversions; do not cut/crush/chew tab
Renal dosing
- [see below]
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
Hepatic dosing
- Child-Pugh Class B: give qd; Child-Pugh Class C: avoid use
SRC: NLM .