Bevacizumab-awwb Dosage

Generic name: Bevacizumab-awwb
Brand name: Mvasi
Drug class: VEGF/VEGFR inhibitors

Medically reviewed by  A Ras MD.

 

Adult Dosing

Dosage forms:  INJ

Special Note

Uses, dosing may vary

• Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments; D/C >28 days before elective surgery, restart >28 days after major surgery when wound fully healed

Colorectal CA, metastatic

[combo w/ bolus-IFL]

• Dose: 5 mg/kg/dose IV x1 on day 1 of 14-day cycle

[combo w/ FOLFOX4]

• Dose: 10 mg/kg/dose IV x1 on day 1 of 14-day cycle

[combo w/ fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin]

• Dose: 5 mg/kg/dose IV x1 on day 1 of 14-day cycle; Alt: 7.5 mg/kg/dose IV x1 on day 1 of 21-day cycle; Info: for pts w/ progressive dz on bevacizumab-containing regimen

Nonsquamous non-small cell lung CA, first-line tx

[15 mg/kg/dose IV x1 on day 1 of 21-day cycle]

Info: for pts w/ unresectable, locally advanced, recurrent or metastatic dz; part of multi-drug chemo regimen

Glioblastoma multiforme, recurrent

[10 mg/kg/dose IV x1 on day 1 of 14-day cycle]

Renal cell CA, metastatic

[10 mg/kg/dose IV x1 on day 1 of 14-day cycle]

Info: use w/ interferon alfa

Cervical CA, persistent or recurrent or metastatic

[15 mg/kg/dose IV x1 on day 1 of 21-day cycle]

Info: part of multi-drug chemo regimen

Ovarian CA

[stage III-IV dz]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle for up to 22 cycles; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA following initial surgical resection; part of multi-drug chemo regimen for up to 1st 6 cycles

[*first-line tx, advanced homologous recombination deficiency-positive dz]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle x15mo; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; use w/ platinum-based chemo for at least 4 cycles, then use w/ olaparib maintenance tx for total of 15mo

[recurrent, platinum-sensitive dz]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; part of multi-drug chemo regimen for 1st 6-10 cycles

[recurrent, platinum-resistant dz, 14-day cycle]

Dose: 10 mg/kg/dose IV x1 on day 1 of 14-day cycle; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; use w/ paclitaxel, doxorubicin liposomal, or topotecan

[recurrent, platinum-resistant dz, 21-day cycle]

Dose: 15 mg/kg/dose IV x1 on day 1 of 21-day cycle; Info: for epithelial ovarian, fallopian tube, or primary peritoneal CA; use w/ topotecan

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

 

SRC: NLM .