Cancidas Dosage

Generic name: caspofungin
Drug class: Echinocandins

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ

Candidemia

[50 mg IV q24h]

Start: 70 mg IV x1 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture

Candidiasis

[esophageal]

Dose: 50 mg IV q24h; Start: 70 mg IV x1 on day 1; Info: cont. x7-14 days after sx resolution

[intra-abdominal, peritoneal, pleural space]

Dose: 50 mg IV q24h; Start: 70 mg IV x1 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture

[*oropharyngeal]

Dose: 50 mg IV q24h; Start: 70 mg IV x1 on day 1; Info: for fluconazole-refractory dz

[*systemic]

Dose: 50-70 mg IV q24h; Info: dose, duration vary by indication

Febrile neutropenia

[50 mg IV q24h]

Start: 70 mg IV on day 1; Max: 70 mg/day; Info: cont. until resolution of neutropenia, or if fungal infection found cont. x14 days minimum or x7 days after resolution of neutropenia and clinical sx

Aspergillosis, refractory

[50 mg IV q24h]

Start: 70 mg IV x1 on day 1; Max: 70 mg/day; Info: tx duration varies

Endocarditis, candidal

[150 mg IV q24h]

Info: for native valve endocarditis; not 1st-line agent; refer to IDSA and AHA guidelines

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[adjust dose amount]

Child-Pugh Class B: 70 mg x1 on day 1 if indicated, then give 35 mg qd; Child-Pugh Class C: not defined

Recommended Peds Dosing

Dosage forms:  INJ

Candidemia

[3 mo-17 yo]

Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture

Candidiasis

[esophageal, 3 mo-17 yo]

Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. x7-14 days after sx resolution

[intra-abdominal, peritoneal, pleural space, 3 mo-17 yo]

Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. x14 days after last positive culture

Febrile neutropenia

[3 mo-17 yo]

Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: cont. until resolution of neutropenia, or if fungal infection found cont. x14 days minimum or x7 days after resolution of neutropenia and clinical sx

Aspergillosis, refractory

[3 mo-17 yo]

Dose: 50 mg/m^2/dose IV q24h; Start: 70 mg/m^2 on day 1; Max: 70 mg/day; Info: tx duration varies

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance

 

SRC: NLM .