Carbaglu Dosage
Generic name: carglumic acid
Drug class: Miscellaneous uncategorized agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: DISPERSE TAB: 200 mg
Acute hyperammonemia, N-acetylglutamate synthase deficiency-related
- [100-250 mg/kg/day PO/NG/GT divided bid-qid]
- Info: for adjunct tx; round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals
Chronic hyperammonemia, N-acetylglutamate synthase deficiency-related
- [10-100 mg/kg/day PO/NG/GT divided bid-qid]
- Info: round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals
Acute hyperammonemia, propionic acidemia-related
- [3300 mg/m^2/day PO/NG/GT divided q12h]
- Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
Acute hyperammonemia, methylmalonic acidemia-related
- [3300 mg/m^2/day PO/NG/GT divided q12h]
- Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
Renal dosing
- [acute hyperammonemia, N-acetylglutamate synthase deficiency-related]
- eGFR 30-59: 50-125 mg/kg/day divided bid-qid; eGFR <30: 15-60 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
- HD/PD: not defined
- [chronic hyperammonemia, N-acetylglutamate synthase deficiency-related]
- eGFR 30-59: 5-50 mg/kg/day divided bid-qid; eGFR <30: 2-25 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
- HD/PD: not defined
- [acute hyperammonemia, propionic acidemia-related]
- eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
- HD/PD: not defined
- [acute hyperammonemia, methylmalonic acidemia-related]
- eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
- HD/PD: not defined
Hepatic dosing
- [not defined]
Recommended Peds Dosing
- Dosage forms: DISPERSE TAB: 200 mg
Acute hyperammonemia, N-acetylglutamate synthase deficiency-related
- [100-250 mg/kg/day PO/NG/GT divided bid-qid]
- Info: for adjunct tx; round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals
Chronic hyperammonemia, N-acetylglutamate synthase deficiency-related
- [10-100 mg/kg/day PO/NG/GT divided bid-qid]
- Info: round dose to nearest 100 mg; adjust dose based on plasma ammonia levels; give before meals
Acute hyperammonemia, propionic acidemia-related
- [<15 kg]
- Dose: 150 mg/kg/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
- [>15 kg]
- Dose: 3300 mg/m^2/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
Acute hyperammonemia, methylmalonic acidemia-related
- [<15 kg]
- Dose: 150 mg/kg/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
- [>15 kg]
- Dose: 3300 mg/m^2/day PO/NG/GT divided q12h; Max: 7 days; Info: for adjunct tx; round dose up to next 50 mg; give before meals
Renal dosing
- [acute hyperammonemia, N-acetylglutamate synthase deficiency-related]
- eGFR 30-59: 50-125 mg/kg/day divided bid-qid; eGFR <30: 15-60 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
- HD/PD: not defined
- [chronic hyperammonemia, N-acetylglutamate synthase deficiency-related]
- eGFR 30-59: 5-50 mg/kg/day divided bid-qid; eGFR <30: 2-25 mg/kg/day divided bid-qid; Info: round dose to nearest 50 mg
- HD/PD: not defined
- [acute hyperammonemia, propionic acidemia-related, <15 kg]
- eGFR 30-59: 75 mg/kg/day divided q12h; eGFR <30: 25 mg/kg/day divided q12h; Info: round dose up to next 50 mg
- HD/PD: not defined
- [acute hyperammonemia, propionic acidemia-related, >15 kg]
- eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
- HD/PD: not defined
- [acute hyperammonemia, methylmalonic acidemia-related, <15 kg]
- eGFR 30-59: 75 mg/kg/day divided q12h; eGFR <30: 25 mg/kg/day divided q12h; Info: round dose up to next 50 mg
- HD/PD: not defined
- [acute hyperammonemia, methylmalonic acidemia-related, >15 kg]
- eGFR 30-59: 1700 mg/m^2/day divided q12h; eGFR <30: 550 mg/m^2/day divided q12h; Info: round dose up to next 50 mg
- HD/PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .