Coreg CR Dosage
Generic name: carvedilol
Brand names: Coreg, Coreg CR
Drug class: Non-cardioselective beta blockers
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: ER CAP: 10 mg, 20 mg, 40 mg, 80 mg
Hypertension
- [initial tx]
- Dose: 20-80 mg PO qam; Start: 20 mg PO qam, may incr. q1-2wk to 40 mg PO qam, then 80 mg PO qam; Max: 80 mg/day; Info: give w/ food; taper dose over 1-2wk to D/C
- [conversion from IR form]
- Dose: 20-80 mg PO qam; Max: 80 mg/day; Info: 6.25 mg/day IR = 10 mg/day ER; may incr. dose q1-2wk; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then may incr. dose q2wk; give w/ food; taper dose over 1-2wk to D/C
Heart failure
- [initial tx]
- Dose: 20-80 mg PO qam; Start: 10 mg PO qam, may incr. q2wk to 20 mg PO qam, then 40 mg PO qam, then 80 mg PO qam; Max: 80 mg/day; Info: minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C
- [conversion from IR form]
- Dose: 20-80 mg PO qam; Max: 80 mg/day; Info: 6.25 mg/day IR = 10 mg/day ER; may incr. dose q2wk; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then may incr. dose q2wk; minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C
Left ventricular dysfunction
- [initial tx]
- Dose: 80 mg PO qam; Start: 20 mg PO qam ASAP after pt stable, then incr. q3-10 days to 40 mg PO qam, then 80 mg PO qam; Info: minimize fluid retention prior to tx; start 10 mg PO qam and/or titrate slower if fluid retention, hypotension, or bradycardia; give w/ food; taper dose over 1-2wk to D/C
- [conversion from IR form]
- Dose: 80 mg PO qam; Info: 6.25 mg/day IR = 10 mg/day ER; incr. dose q3-10 days; in pts 65 yo and older or at risk of hypotension, dizziness, or syncope on 25 mg/day IR or 50 mg/day IR, switch to 20 mg/day ER or 40 mg/day ER, respectively, then incr. dose q2wk; minimize fluid retention prior to tx; give w/ food; taper dose over 1-2wk to D/C
Renal dosing
- renal impairment: not defined, caution advised
- HD/PD: not defined
Hepatic dosing
- hepatic impairment: avoid use
SRC: NLM .