Corlanor Dosage
Generic name: ivabradine
Drug class: Miscellaneous cardiovascular agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 5 mg, 7.5 mg; SOL: 1 mg per mL
Heart failure
- [2.5-7.5 mg PO bid]
- Start: 5 mg PO bid x2wk, then may adjust dose by 5 mg/day to maintain resting HR 50-60; Max: 15 mg/day; Info: for pts w/ LVEF 35% or lower and resting HR at least 70; start 2.5 mg PO bid in pts w/ conduction defect hx or hemodynamic compromise risk; give w/ meals
Renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
Hepatic dosing
- [see below]
- Child-Pugh Class C: contraindicated
Recommended Peds Dosing
- Dosage forms: TAB: 5 mg, 7.5 mg; SOL: 1 mg per mL
Heart failure, dilated cardiomyopathy
- [6-11 mo, <40 kg]
- Dose: 0.05-0.2 mg/kg/dose PO bid; Start: 0.05 mg/kg/dose PO bid, then may adjust dose by 0.1 mg/kg/day q2wk to target HR decr. at least 20% as tolerated; Max: 0.2 mg/kg/dose; 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; give w/ meals
- [1 yo and older, <40 kg]
- Dose: 0.05-0.3 mg/kg/dose PO bid; Start: 0.05 mg/kg/dose PO bid, then may adjust dose by 0.1 mg/kg/day q2wk to target HR decr. at least 20% as tolerated; Max: 0.3 mg/kg/dose; 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; give w/ meals
- [6 mo and older, >40 kg]
- Dose: 2.5-7.5 mg PO bid; Start: 2.5 mg PO bid, then may adjust dose by 5 mg/day q2wk to target HR decr. at least 20% as tolerated; Max: 15 mg/day; Info: for pts in sinus rhythm w/ elev. HR; give w/ meals
Renal dosing
- [see below]
- CrCl >15: no adjustment; CrCl <15: not defined
- HD/PD: not defined
Hepatic dosing
- [see below]
- Child-Pugh Class C: contraindicated
SRC: NLM .