Crestor Dosage

Generic name: rosuvastatin
Drug class: Statins

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 5 mg, 10 mg, 20 mg, 40 mg

Hypercholesterolemia

[5-40 mg PO qd]

Start: 10-20 mg PO qd; Max: 40 mg/day; Info: may adjust dose q2-4wk; consider starting 5 mg PO qd in Asian pts (risk of increase drug levels)

Mixed dyslipidemia

[5-40 mg PO qd]

Start: 10-20 mg PO qd; Max: 40 mg/day; Info: may adjust dose q2-4wk; consider starting 5 mg PO qd in Asian pts (risk of increase. drug levels)

Hypertriglyceridemia

[5-40 mg PO qd]

Start: 10-20 mg PO qd; Max: 40 mg/day; Info: may adjust dose q2-4wk; consider starting 5 mg PO qd in Asian pts (risk of increase. drug levels)

Dysbetalipoproteinemia

[5-40 mg PO qd]

Start: 10-20 mg PO qd; Max: 40 mg/day; Info: may adjust dose q2-4wk; consider starting 5 mg PO qd in Asian pts (risk of increase. drug levels)

Homozygous familial hypercholesterolemia

[20-40 mg PO qd]

Start: 20 mg PO qd; Max: 40 mg/day; Info: may adjust dose q2-4wk; consider starting 5 mg PO qd in Asian pts (risk of increase. drug levels)

Cardiovascular event risk reduction

[5-40 mg PO qd]

Info: consider starting 5 mg PO qd in Asian pts (risk of increase. drug levels)

Atherosclerotic cardiovascular disease

[5-40 mg PO qd]

Info: may adjust dose q2-4wk; consider starting 5 mg PO qd in Asian pts (risk of increase drug levels); refer to ACC/AHA cholesterol guideline

Renal dosing

[adjust dose amount]

CrCl <30: start 5 mg qd, max 10 mg qd

HD: start 2.5 mg qd, max 10 mg qd; no supplement after dialysis; PD: not defined

Hepatic dosing

active hepatic disease or unexplained elevated LFTs: contraindicated

 Recommended Peds Dosing

Dosage forms:  TAB: 5 mg, 10 mg, 20 mg, 40 mg

Heterozygous familial hypercholesterolemia

[8-9 yo]

Dose: 5-10 mg PO qd; Max: 10 mg/day; Info: may adjust dose q4wk; consider starting 5 mg PO qd in Asian pts (risk of incr. drug levels)

[10-17 yo]

Dose: 5-20 mg PO qd; Start: 5-10 mg PO qd; Max: 20 mg/day; Info: may adjust dose q4wk; consider starting 5 mg PO qd in Asian pts (risk of increase. drug levels)

Homozygous familial hypercholesterolemia

[7-17 yo]

Dose: 20 mg PO qd; Info: consider starting 5 mg PO qd in Asian pts (risk of increase. drug levels)

Renal dosing

[adjust dose amount]

CrCl <30: start 5 mg qd, max 10 mg qd

HD: start 2.5 mg qd, max 10 mg qd; no supplement after dialysis; PD: not defined

Hepatic dosing

active hepatic disease or unexplained elevated. LFTs: contraindicated

 

 

SRC: NLM .