DDAVP Dosage

Generic name: desmopressin (nasal)
Brand names: DDAVP Nasal, DDAVP Rhinal Tube, Noctiva, Stimate
Drug class: Antidiuretic hormones

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 0.1 mg, 0.2 mg; INJ: various

Diabetes insipidus, central

[PO route]

Dose: 0.1-1.2 mg/day PO divided bid-tid; Start: 0.05 mg PO bid; Max: 1.2 mg/day; Info: give 1st PO dose 12h after last intranasal dose when switching to PO; restrict fluid intake

[parenteral route]

Dose: 1-2 mcg SC/IV bid; Info: parenteral dose is approx. 1/10 of intranasal dose; restrict fluid intake

Nocturnal enuresis

[0.2-0.6 mg PO qhs]

Start: 0.2 mg PO qhs; Max: 0.6 mg/day; Info: restrict fluid intake >1h before admin. until next morning or >8h after admin; hold tx if acute illness w/ fluid and electrolyte imbalance risk

Renal concentration capacity test

[0.6 mg PO qhs x1]

Info: give dose after bladder emptied

Hemophilia A

[0.3 mcg/kg/dose IV x1]

Info: for pts w/ factor VIII levels >5%; if preop, give 30min before surgery

Type I von Willebrand dz, mild-moderate

[0.3 mcg/kg/dose IV x1]

Info: for pts w/ factor VIII levels >5%; if preop, give 30min before surgery

Uremic bleeding

[0.3 mcg/kg/dose SC/IV x1]

Info: IV route preferred to SC route

Renal dosing

[*uremic bleeding]

renal impairment: not defined

HD/PD: not defined

[all other indications]

CrCl <50: contraindicated

HD/PD: not defined

Hepatic dosing

[not defined]

 Recommended Peds Dosing

Dosage forms:  TAB: 0.1 mg, 0.2 mg; INJ: various

Diabetes insipidus, central

[<4 yo]

Dose: 0.1-0.8 mg/day PO divided bid; Start: 0.05 mg PO qd; Info: give 1st PO dose 12h after last intranasal dose when switching to PO; restrict fluid intake

[4-12 yo]

Dose: 0.1-1.2 mg/day PO divided bid-tid; Start: 0.05 mg PO bid; Max: 1.2 mg/day; Info: give 1st PO dose 12h after last intranasal dose when switching to PO; restrict fluid intake

[12 yo and older]

Dose: 0.1-1.2 mg/day PO divided bid-tid; Start: 0.05 mg PO bid; Max: 1.2 mg/day PO, 4 mcg/day SC/IV; Alt: 1-2 mcg SC/IV bid; Info: give 1st PO dose 12h after last intranasal dose when switching to PO; parenteral dose is approx. 1/10 of intranasal dose; restrict fluid intake

Nocturnal enuresis

[6 yo and older]

Dose: 0.2-0.6 mg PO qhs; Start: 0.2 mg PO qhs; Max: 0.6 mg/day; Info: restrict fluid intake >1h before admin. until next morning or >8h after admin; hold tx if acute illness w/ fluid and electrolyte imbalance risk

Renal concentration capacity test

[3 yo and older]

Dose: 0.6 mg PO qhs x1; Info: give dose after bladder emptied

Hemophilia A

[3 mo and older]

Dose: 0.3 mcg/kg/dose IV x1; Info: for pts w/ factor VIII levels >5%; if preop, give 30min before surgery

Type I von Willebrand dz, mild-moderate

[3 mo and older]

Dose: 0.3 mcg/kg/dose IV x1; Info: for pts w/ factor VIII levels >5%; if preop, give 30min before surgery

Uremic bleeding

[3 mo and older]

Dose: 0.3 mcg/kg/dose SC/IV x1; Info: IV route preferred to SC route

Renal dosing

[*uremic bleeding]

renal impairment: not defined

HD/PD: not defined

[all other indications]

CrCl <50: contraindicated

HD/PD: not defined

Hepatic dosing

[not defined]

 

SRC: NLM .