Decitabine Dosage
Generic name: decitabine
Brand name: Dacogen
Drug class: Antimetabolites
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Myelodysplastic syndrome
- [3-day regimen]
- Dose: 15 mg/m^2/dose IV q8h on days 1-3 of 42-day cycle; Info: give for at least 4 cycles
- [5-day regimen]
- Dose: 20 mg/m^2/dose IV x1 on days 1-5 of 28-day cycle; Info: give for at least 4 cycles
AML, newly diagnosed
- [20 mg/m^2/dose IV x1 on days 1-5 of 28-day cycle]
- Info: for pts 75 yo and older, or who are ineligible for intensive induction chemo d/t comorbidities; use w/ venetoclax; cytoreduction may be required if WBC >25,000 prior to 1st dose
Renal dosing
- renal impairment: not defined, caution advised
- HD/PD: not defined
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
SRC: NLM .