Defitelio Dosage
Generic name: defibrotide
Drug class: Miscellaneous coagulation modifiers
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Hepatic veno-occlusive dz
- [6.25 mg/kg/dose IV q6h for at least 21 days]
- Max: 60 days; Info: for pts w/ renal or pulmonary dysfunction after hematopoietic stem cell transplant; dose based on wt prior to transplant; D/C at least 2h before invasive procedure
Renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
Hepatic dosing
- [not defined]
Recommended Peds Dosing
- Dosage forms: INJ
Hepatic veno-occlusive dz
- [6.25 mg/kg/dose IV q6h for at least 21 days]
- Max: 60 days; Info: for pts w/ renal or pulmonary dysfunction after hematopoietic stem cell transplant; dose based on wt prior to transplant; D/C at least 2h before an invasive procedure
Renal dosing
- [see below]
- renal impairment: no adjustment
- HD: no adjustment; no supplement; PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .