Empaveli Dosage
Generic name: pegcetacoplan
Dosage form: injection, for subcutaneous use
Drug class: Selective immunosuppressants
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Restricted Distribution in US
- [1-888-343-7073 or www.empavelirems.com for more info]
Paroxysmal nocturnal hemoglobinuria
- [1080 mg SC 2x/wk]
- Info: give meningococcal, pneumococcal and haemophilus b vaccines >2wk before tx per ACIP guidelines, or give 2wk antibacterial prophylaxis if tx must start w/in 2wk of vaccination; when switching from eculizumab, initiate 1st pegcetacoplan dose 4wk before D/C eculizumab; when switching from ravulizumab, initiate 1st pegcetacoplan dose w/in 4wk after last ravulizumab dose; incr. dose to 1080 mg SC q3 days if LDH >2x ULN, then monitor LDH 2x/wk for at least 4wk
Renal dosing
- renal impairment: no adjustment
- HD/PD: not defined
Hepatic dosing
- [no adjustment]
SRC: NLM .