Entrectinib Dosage

Generic name: entrectinib
Brand name: Rozlytrek
Dosage form: oral capsule (100 mg; 200 mg)
Drug class: Multikinase inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 100 mg, 200 mg

Non-small cell lung CA, metastatic

[600 mg PO qd]

Info: for pts w/ ROS1-positive dz; do not open/crush/chew/dissolve cap

Neurotrophic receptor tyrosine kinase (NTRK) gene fusion-positive solid tumors, metastatic or unresectable

[600 mg PO qd]

Info: for refractory dz; do not open/crush/chew/dissolve cap

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

Hepatic dosing

bilirubin 1-1.5x ULN: no adjustment; bilirubin >1.5x ULN: not defined

Recommended Peds Dosing

Dosage forms:  CAP: 100 mg, 200 mg

Neurotrophic receptor tyrosine kinase (NTRK) gene fusion-positive solid tumors, metastatic or unresectable

[12 yo and older, BSA 0.91-1.1 m^2]

Dose: 400 mg PO qd; Info: for refractory dz; do not open/crush/chew/dissolve cap

[12 yo and older, BSA 1.11-1.5 m^2]

Dose: 500 mg PO qd; Info: for refractory dz; do not open/crush/chew/dissolve cap

[12 yo and older, BSA >1.5 m^2]

Dose: 600 mg PO qd; Info: for refractory dz; do not open/crush/chew/dissolve cap

Renal dosing

CrCl >30: no adjustment; CrCl <30: not defined

HD/PD: not defined

Hepatic dosing

bilirubin 1-1.5x ULN: no adjustment; bilirubin >1.5x ULN: not defined