Eprontia Dosage
Generic name: topiramate
Dosage form: oral solution
Drug class: Carbonic anhydrase inhibitor anticonvulsants
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: SOL: 25 mg per mL
Partial seizures
- [monotherapy]
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: taper dose gradually to D/C
- [adjunct tx]
- Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective, may incr. ADR risk; taper dose gradually to D/C
Seizures, primary generalized tonic clonic
- [monotherapy]
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: taper dose gradually to D/C
- [adjunct tx]
- Dose: 200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: taper dose gradually to D/C
Seizures, Lennox-Gastaut syndrome
- [adjunct tx]
- Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, incr. by 25-50 mg/day qwk; Info: taper dose gradually to D/C
Migraine headache prophylaxis
- [50 mg PO bid]
- Start: 25 mg PO qhs x1wk, incr. by 25 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C
Renal dosing
- [adjust dose amount]
- CrCl <70: decr. usual dose by 50%
- HD: decr. usual dose, amount not defined, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
Recommended Peds Dosing
- Dosage forms: SOL: 25 mg per mL
Partial seizures
- [monotherapy, 2-9 yo, <11 kg]
- Dose: 75-125 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 250 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, 12-22 kg]
- Dose: 100-150 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 300 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, 23-31 kg]
- Dose: 100-175 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, 32-38 kg]
- Dose: 125-175 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, >39 kg]
- Dose: 125-200 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 400 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 10 yo and older]
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: taper dose gradually to D/C
- [adjunct tx, 2-16 yo]
- Dose: 5-9 mg/kg/day PO divided bid; Start: 1-3 mg/kg/dose up to 25 mg PO qhs x1wk, incr. by 1-3 mg/kg/day q1-2wk; Max: 400 mg/day; Info: taper dose gradually to D/C
Seizures, primary generalized tonic clonic
- [monotherapy, 2-9 yo, <11 kg]
- Dose: 75-125 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 250 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, 12-22 kg]
- Dose: 100-150 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 300 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, 23-31 kg]
- Dose: 100-175 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, 32-38 kg]
- Dose: 125-175 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 350 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 2-9 yo, >39 kg]
- Dose: 125-200 mg PO bid; Start: 25 mg PO qhs x1wk, then 25 mg PO bid x1wk, then incr. by 25-50 mg/day qwk; Max: 400 mg/day; Info: taper dose gradually to D/C
- [monotherapy, 10 yo and older]
- Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, incr. by 50 mg/day qwk until 100 mg PO bid, then incr. by 100 mg/day qwk; Info: taper dose gradually to D/C
- [adjunct tx, 2-16 yo]
- Dose: 5-9 mg/kg/day PO divided bid; Start: 1-3 mg/kg/dose up to 25 mg PO qhs x1wk, incr. by 1-3 mg/kg/day q1-2wk; Max: 400 mg/day; Info: taper dose gradually to D/C
Seizures, Lennox-Gastaut syndrome
- [adjunct tx, 2-16 yo]
- Dose: 5-9 mg/kg/day PO divided bid; Start: 1-3 mg/kg/dose up to 25 mg PO qhs x1wk, incr. by 1-3 mg/kg/day q1-2wk; Max: 400 mg/day; Info: taper dose gradually to D/C
Migraine headache prophylaxis
- [12 yo and older]
- Dose: 50 mg PO bid; Start: 25 mg PO qhs x1wk, incr. by 25 mg/day qwk; Max: 200 mg/day; Info: taper dose gradually to D/C
Renal dosing
- [adjust dose amount]
- CrCl <70: decr. usual dose by 50%
- HD: decr. usual dose, amount not defined, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: not defined
Hepatic dosing
- [not defined]
- hepatic impairment: caution advised
SRC: NLM .