Ethambutol Dosage
Generic name: ethambutol
Brand name: Myambutol
Drug class: Miscellaneous antituberculosis agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 100 mg, 400 mg
Tuberculosis, active
- [40-55 kg]
- Dose: 800 mg PO qd; Alt: 800 mg PO 5x/wk if directly observed tx; 1200 mg PO 3x/wk or 2000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen
- [56-75 kg]
- Dose: 1200 mg PO qd; Alt: 1200 mg PO 5x/wk if directly observed tx; 2000 mg PO 3x/wk or 2800 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen
- [76-90 kg]
- Dose: 1600 mg PO qd: Alt: 1600 mg PO 5x/wk if directly observed tx; 2400 mg PO 3x/wk or 4000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen
MAC tx, disseminated
- [15 mg/kg/dose PO qd]
- Info: use w/ clarithromycin or azithromycin
MAC prophylaxis, secondary
- [15 mg/kg/dose PO qd]
- Info: use w/ clarithromycin or azithromycin
Renal dosing
- [adjust dose frequency]
- CrCl <30: 15-25 mg/kg/dose 3x/wk
- HD: 15-25 mg/kg/dose 3x/wk after dialysis; no supplement; PD: 15-25 mg/kg/dose 3x/wk; no supplement
Hepatic dosing
- [not defined]
Recommended Peds Dosing
- Dosage forms: TAB: 100 mg, 400 mg
Tuberculosis, active
- [<5 yo]
- Dose: 15-25 mg/kg/dose PO qd; Max: 1000 mg/day; Alt: 15-25 mg/kg/dose PO 5x/wk if directly observed tx; Info: part of multi-drug regimen; only for isoniazid or rifampin resistance
- [5 yo and older, <40 kg]
- Dose: 15-25 mg/kg/dose PO qd; Max: 1000 mg/day; Alt: 15-25 mg/kg/dose PO 5x/wk if directly observed tx; 50 mg/kg/dose PO 2x/wk if directly observed tx, max 2500 mg/dose; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen
- [5 yo and older, 40-55 kg]
- Dose: 800 mg PO qd; Alt: 800 mg PO 5x/wk if directly observed tx; 1200 mg PO 3x/wk or 2000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen
- [5 yo and older, 56-75 kg]
- Dose: 1200 mg PO qd; Alt: 1200 mg PO 5x/wk if directly observed tx; 2000 mg PO 3x/wk or 2800 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen
- [5 yo and older, 76-90 kg]
- Dose: 1600 mg PO qd: Alt: 1600 mg PO 5x/wk if directly observed tx; 2400 mg PO 3x/wk or 4000 mg PO 2x/wk if directly observed tx; Info: use lean body wt; refer to Lean Body Weight (Female) and Lean Body Weight (Male) calculators; part of multi-drug regimen
MAC tx, disseminated
- [1 mo-12 yo]
- Dose: 15-25 mg/kg/dose PO qd; Max: 2500 mg/day; Info: use w/ clarithromycin or azithromycin
- [13 yo and older]
- Dose: 15 mg/kg/dose PO qd; Info: use w/ clarithromycin or azithromycin
MAC prophylaxis, secondary
- [1 mo-12 yo]
- Dose: 15-25 mg/kg/dose PO qd; Max: 2500 mg/day; Info: use w/ clarithromycin or azithromycin
- [13 yo and older]
- Dose: 15 mg/kg/dose PO qd; Info: use w/ clarithromycin or azithromycin
Renal dosing
- [adjust dose frequency]
- CrCl 10-50: 15-25 mg/kg/dose q24-36h; CrCl <10: 15-25 mg/kg/dose q48h
- HD: 15-25 mg/kg/dose 3x/wk after dialysis; no supplement; PD: 15-25 mg/kg/dose 3x/wk; no supplement
Hepatic dosing
- [not defined]
SRC: NLM .