Ferriprox Dosage
Generic name: deferiprone
Drug classes: Antidotes, Chelating agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB (tid): 500 mg, 1000 mg; TAB (bid): 1000 mg; SOL: 100 mg per mL
Iron overload, chronic transfusional
- [solution form]
- Dose: 25-33 mg/kg/dose PO tid; Start: 25 mg/kg/dose PO tid; Max: 99 mg/kg/day; Alt: start 15 mg/kg/dose PO tid, incr. by 5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest 2.5 mL; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
- [tid tablet form]
- Dose: 25-33 mg/kg/dose PO tid; Start: 25 mg/kg/dose PO tid; Max: 99 mg/kg/day; Alt: start 15 mg/kg/dose PO tid, incr. by 5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest half-tab; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
- [bid tablet form]
- Dose: 37.5-49.5 mg/kg/dose PO bid; Start: 37.5 mg/kg/dose PO bid; Max: 99 mg/kg/day; Alt: start 22.5 mg/kg/dose PO bid, incr. by 7.5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest half-tab; give w/ food; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
Renal dosing
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
Hepatic dosing
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
Recommended Peds Dosing
- Dosage forms: Tab Sizes / Dosage FormsTAB (tid): 500 mg, 1000 mg; TAB (bid): 1000 mg; SOL: 100 mg per mL
Iron overload, chronic transfusional
- [solution form, 3 yo and older]
- Dose: 25-33 mg/kg/dose PO tid; Start: 25 mg/kg/dose PO tid; Max: 99 mg/kg/day; Alt: start 15 mg/kg/dose PO tid, incr. by 5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest 2.5 mL; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
- [tid tablet form, 8 yo and older]
- Dose: 25-33 mg/kg/dose PO tid; Start: 25 mg/kg/dose PO tid; Max: 99 mg/kg/day; Alt: start 15 mg/kg/dose PO tid, incr. by 5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest half-tab; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
- [bid tablet form, 8 yo and older]
- Dose: 37.5-49.5 mg/kg/dose PO bid; Start: 37.5 mg/kg/dose PO bid; Max: 99 mg/kg/day; Alt: start 22.5 mg/kg/dose PO bid, incr. by 7.5 mg/kg/dose qwk; Info: for pts w/ thalassemia syndromes, sickle cell dz, or other transfusion-dependent anemias; round dose to nearest half-tab; give w/ food; adjust dose q2-3mo based on serum ferritin levels; may interrupt tx if serum ferritin levels consistently <500 mcg/L; interrupt tx if ANC <1500
Renal dosing
- eGFR >15: no adjustment; eGFR <15: not defined
- HD/PD: not defined
Hepatic dosing
- Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined
SRC: NLM .