Flolan Dosage

Generic name: epoprostenol
Brand names: Flolan, Veletri
Drug class: Agents for pulmonary hypertension

Medically reviewed by  A Ras MD

Recommended Adult Dosing

Dosage forms:  INJ

Restricted Distribution in US

Pulmonary arterial HTN

[IV route]

Dose: individualize dose IV; Start: 2 ng/kg/min IV, may adjust by 1-2 ng/kg/min IV no more frequently than q15min; Info: taper dose gradually to D/C

[*nebulization route]

Dose: individualize dose via continuous NEB; Start: 10-50 ng/kg/min continuous NEB, then titrate to effect; Info: refer to institution protocol; taper dose gradually to D/C

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ

Restricted Distribution in US

Pulmonary arterial HTN

[IV route, 1 mo and older]

Dose: individualize dose IV; Start: 1-2 ng/kg/min IV, may incr. by 2 ng/kg/min IV no more frequently than q15min; Info: if sx persist or recur after initial improvement, incr. dose by 1-2 ng/kg/min IV no more frequently than q15min; very young children may require higher doses; taper dose gradually to D/C

[nebulization route, 1 mo and older]

Dose: individualize dose via continuous NEB; Start: 20-50 ng/kg/min continuous NEB, then titrate to effect; Info: refer to institution protocol; taper dose gradually to D/C

Persistent pulmonary HTN of newborn, refractory

[<1 mo]

Dose: individualize dose via continuous NEB; Start: 20-50 ng/kg/min continuous NEB, then titrate to effect; Info: refer to institution protocol; taper dose gradually to D/C

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .