Hyzaar Dosage
Generic name: hydrochlorothiazide and losartan
Drug class: Angiotensin II inhibitors with thiazides
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 50 mg/12.5 mg, 100 mg/12.5 mg, 100 mg/25 mg
Hypertension
- [1 tab PO qd]
- Start: 50 mg/12.5 mg PO qd if on HCTZ 25 mg/day or losartan 50 mg/day or as initial tx for severe HTN; 100 mg/12.5 mg PO qd if on losartan 100 mg/day; may incr. to 100 mg/25 mg PO qd after 3wk if inadequate response; Max: 100 mg/25 mg/day
Stroke prevention
- [1 tab PO qd]
- Start: 50 mg/12.5 mg PO qd if on losartan 50 mg/day, may incr. to 100 mg/12.5 mg PO qd, then may incr. to 100 mg/25 mg PO qd if needed; Max: 100 mg/25 mg/day; Info: for pts w/ HTN and LVH; possibly ineffective in Black pts; not for initial tx
Renal dosing
- CrCl >30: no adjustment; CrCl 10-30: not defined, caution advised; CrCl <10: avoid use; anuria: contraindicated
- HD/PD: avoid use
Hepatic dosing
- hepatic impairment: avoid use as initial tx; Info: lower losartan doses not possible w/ fixed-dose combo
SRC: NLM .