Ilaris Dosage
Generic name: canakinumab
Drug class: Interleukin inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ: 150 mg per mL
Cryopyrin-assoc. periodic syndromes
- [<41 kg]
- Dose: 2 mg/kg/dose SC q8wk
- [>41 kg]
- Dose: 150 mg SC q8wk
TNF receptor-assoc. periodic syndrome
- [<41 kg]
- Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response
- [>41 kg]
- Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response
Hyperimmunoglobulin D syndrome/mevalonate kinase deficiency
- [<41 kg]
- Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response
- [>41 kg]
- Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response
Familial Mediterranean fever
- [<41 kg]
- Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response
- [>41 kg]
- Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response
Adult-onset Still dz
- [4 mg/kg/dose SC q4wk]
- Max: 300 mg/dose
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
Recommended Peds Dosing
- Dosage forms: INJ: 150 mg per mL
Cryopyrin-assoc. periodic syndromes
- [4 yo and older, 15-40 kg]
- Dose: 2 mg/kg/dose SC q8wk; Info: may incr. to 3 mg/kg/dose SC q8wk if inadequate response
- [4 yo and older, >41 kg]
- Dose: 150 mg SC q8wk
TNF receptor-assoc. periodic syndrome
- [<41 kg]
- Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response
- [>41 kg]
- Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response
Hyperimmunoglobulin D syndrome/mevalonate kinase deficiency
- [<41 kg]
- Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response
- [>41 kg]
- Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response
Familial Mediterranean fever
- [<41 kg]
- Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response
- [>41 kg]
- Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response
Systemic juvenile idiopathic arthritis
- [2 yo and older, >7.5 kg]
- Dose: 4 mg/kg/dose SC q4wk; Max: 300 mg/dose
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .