Imbruvica Dosage

Generic name: ibrutinib
Drug class: BTK inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 70 mg, 140 mg; TAB: 140 mg, 280 mg, 420 mg, 560 mg

Mantle cell lymphoma, relapsed or refractory

[560 mg PO qd]

Info: do not open cap; do not cut/crush/chew tab

CLL/SLL

[420 mg PO qd]

Info: use as monotherapy, w/ obinutuzumab, w/ rituximab, or part of multi-drug chemo regimen; do not open cap; do not cut/crush/chew tab

Waldenstrom macroglobulinemia

[420 mg PO qd]

Info: use as monotherapy or w/ rituximab; do not open cap; do not cut/crush/chew tab

Marginal zone lymphoma, relapsed or refractory

[560 mg PO qd]

Info: do not open cap; do not cut/crush/chew tab

Chronic GVHD, refractory

[420 mg PO qd]

Info: do not open cap; do not cut/crush/chew tab

Renal dosing

CrCl >25: no adjustment; CrCl <25: not defined

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A: 140 mg qd; Child-Pugh Class B: 70 mg qd; Child-Pugh Class C: avoid use

SRC: NLM .