Istodax Dosage

Generic name: romidepsin
Drug class: Histone deacetylase inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Cutaneous T-cell lymphoma, refractory

[14 mg/m^2/dose IV x1 on days 1, 8, 15 of 28-day cycle]

Peripheral T-cell lymphoma, refractory

[indication withdrawn in US]

Info: drug not shown to improve survival in pts w/ peripheral T-cell lymphoma

Renal dosing

CrCl >15: no adjustment; CrCl <15: not defined

HD/PD: not defined

Hepatic dosing

bilirubin 1.6-3x ULN and any AST: start 7 mg/m^2/dose; bilirubin >3x ULN and any AST: start 5 mg/m^2/dose

SRC: NLM .