Jynarque Dosage
Generic name: tolvaptan
Brand names: Jynarque, Samsca
Recommended Adult Dosing
Dosage forms: TAB: 15 mg, 30 mg, 45 mg, 60 mg, 90 mg
Restricted Distribution in US
Autosomal dominant polycystic kidney dz
- [60-120 mg/day PO divided bid]
- Start: 45 mg PO qam and 15 mg PO qpm, may incr. to 60 mg PO qam and 30 mg PO qpm, then to 90 mg PO qam and 30 mg PO qpm; Info: for slowing kidney fxn decline; give 1st dose in am, 2nd dose 8h later; may incr. dose no more frequently than qwk; avoid fluid restriction during tx
Renal dosing
- CrCl >60: no adjustment; CrCl 10-60: not defined, caution advised; CrCl <10: avoid use; anuria: contraindicated
- HD/PD: not defined
Hepatic dosing
- hepatic dz (except uncomplicated polycystic liver dz): contraindicated