Kadian Dosage
Generic name: morphine (oral)
Brand names: Kadian, MS Contin
Drug class: Narcotic analgesics
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: ER CAP: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 80 mg, 100 mg, 200 mg
Pain, mod-severe chronic
- [opioid-nontolerant pts]
- Dose: individualize dose PO q12-24h; Start: 30 mg PO q24h, may incr. dose q1-2 days; Info: use alternative in opioid-naive pts; use lowest effective dose, shortest effective tx duration; consider low start dose, titrate slowly in pts 65 yo and older; may open cap, but do not crush/chew/dissolve contents; >60 mg/dose, >120 mg/day, 100 mg cap, 200 mg cap for use in opioid-tolerant pts only; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
- [opioid-tolerant pts]
- Dose: individualize dose PO q12-24h; Start: individualize based on current opioid intake, see pkg insert for conversion; Info: use lowest effective dose, shortest effective tx duration; may incr. dose q1-2 days; consider low start dose, titrate slowly in pts 65 yo and older; may open cap, but do not crush/chew/dissolve contents; taper total daily dose by no more than 10-25% q2-4wk to D/C if long-term use
Renal dosing
- CrCl 10-50: decr. usual dose by 25%, titrate slowly; CrCl <10: avoid use
- HD/PD: avoid use
Hepatic dosing
- [adjust dose amount]
- cirrhosis: decr. start dose, titrate slowly
SRC: NLM .