Klonopin Dosage

Generic name: clonazepam
Drug classes: Benzodiazepine anticonvulsants, Benzodiazepines

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 0.5 mg, 1 mg, 2 mg

Seizure disorder

[0.5-5 mg PO tid]

Start: 0.5 mg PO tid, may incr. by 0.5-1 mg/day q3 days; Max: 20 mg/day; Info: taper dose gradually to D/C

Panic disorder

[0.5-2 mg PO bid]

Start: 0.25 mg PO bid, incr. by 0.25-0.5 mg/day q3 days; Max: 4 mg/day; Info: consider lower start dose in elderly pts; taper dose by 0.25 mg/day q3 days to D/C

Anxiety

[0.25-0.5 mg PO bid-tid]

Start: 0.25 mg PO bid, may incr. by 0.25 mg/day q1-2 days; Max: 4 mg/day; Info: consider lower start dose in elderly pts; taper dose gradually to D/C

Restless legs syndrome

[0.5-2 mg PO qhs]

Start: 30min before bedtime; Info: taper dose gradually to D/C

Confusional arousals

[0.5-2 mg PO qhs]

Info: taper dose gradually to D/C

Sleep terrors

[0.5-2 mg PO qhs]

Info: taper dose gradually to D/C

Sleepwalking

[0.5-2 mg PO qhs]

Info: taper dose gradually to D/C

Rapid eye movement sleep behavior disorder

[0.5-1 mg PO qhs]

Info: taper dose gradually to D/C

Burning mouth syndrome

[0.25-2 mg/day PO divided qd-tid]

Start: 0.25-0.5 mg PO qhs x1wk, may incr. by 0.25-0.5 mg/day qwk; Info: taper dose gradually to D/C

*Tourette syndrome

[0.25-3 mg/day PO divided bid-tid]

Max: 6 mg/day; Info: taper dose gradually to D/C

Renal dosing

renal impairment: no adjustment; Info: caution advised, metabolite accumulation possible

HD: no adjustment; no supplement; PD: not defined; Info: caution advised, metabolite accumulation possible

Hepatic dosing

significant impairment: contraindicated

Recommended Peds Dosing

Dosage forms:  TAB: 0.5 mg, 1 mg, 2 mg

Seizure disorder

[<10 yo or <30 kg]

Dose: 0.1-0.2 mg/kg/day PO divided bid-tid; Start: 0.01-0.03 mg/kg/day PO divided bid-tid, incr. by 0.25-0.5 mg/day q3 days; Info: give largest dose qhs; taper dose gradually to D/C

[10 yo and older or >30 kg]

Dose: 0.5-5 mg PO tid; Start: 0.5 mg PO tid, may incr. by 0.5-1 mg/day q3 days; Max: 20 mg/day; Info: taper dose gradually to D/C

Sleep terrors

[2 yo and older]

Dose: 0.125-0.25 mg PO qhs; Info: taper dose gradually to D/C

Sleepwalking

[2 yo and older]

Dose: 0.125-0.25 mg PO qhs; Info: taper dose gradually to D/C

Rapid eye movement sleep behavior disorder

[2 yo and older]

Dose: 0.25-0.5 mg PO qhs; Info: taper dose gradually to D/C

Tourette syndrome

[6 yo and older]

Dose: 0.25-3 mg/day PO divided bid-tid; Start: 0.25 mg/day PO divided bid-tid, titrate slowly; Max: 6 mg/day; Info: taper dose gradually to D/C

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

significant impairment: contraindicated

 

SRC: NLM .