Linzess Dosage

Generic name: linaclotide
Drug class: Guanylate cyclase-C agonists

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 72 mcg, 145 mcg, 290 mcg

IBS, constipation-predominant

[290 mcg PO qd]

Info: give >30min before 1st meal; may open cap, but do not crush/chew contents

Chronic idiopathic constipation

[145 mcg PO qd]

Info: give >30min before 1st meal; may give 72 mcg PO qd if tolerability concern; may open cap, but do not crush/chew contents

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[no adjustment]

SRC: NLM .