Malarone Dosage

Generic name: atovaquone and proguanil
Brand names: Malarone, Malarone Pediatric
Drug class: Antimalarial combinations

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 250 mg/100 mg

Malaria prophylaxis

[1 tab PO qd]

Start: 1-2 days before exposure; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

Malaria tx, uncomplicated

[4 tabs PO qd x3 days]

Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

Renal dosing

[malaria prophylaxis]

CrCl <30: contraindicated

HD/PD: not defined

[malaria tx]

CrCl >30: no adjustment; CrCl <30: not defined, caution advised

HD/PD: not defined

Hepatic dosing

mild-mod impairment: no adjustment; severe impairment: not defined

Recommended Peds Dosing

Dosage forms:  TAB: 62.5 mg/25 mg, 250 mg/100 mg

Malaria prophylaxis

[*5-8 kg]

Dose: 31.25 mg/12.5 mg PO qd; Start: 1-2 days before exposure; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

[*9-10 kg]

Dose: 46.9 mg/18.7 mg PO qd; Start: 1-2 days before exposure; Info: 1 dose = 3/4 of 62.5 mg/25 mg tab; repeat dose if vomiting occurs w/in 30min; give w/ food or milk; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

[11-20 kg]

Dose: 62.5 mg/25 mg PO qd; Start: 1-2 days before exposure; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

[21-30 kg]

Dose: 125 mg/50 mg PO qd; Start: 1-2 days before exposure; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

[31-40 kg]

Dose: 187.5 mg/75 mg PO qd; Start: 1-2 days before exposure; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

[>41 kg]

Dose: 250 mg/100 mg PO qd; Start: 1-2 days before exposure; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; D/C 7 days after exposure; see CDC Pre-Travel Malaria Prophylaxis recommendations in Guidelines > Specialties > Infectious Diseases

Malaria tx, uncomplicated

[5-7 kg]

Dose: 125 mg/50 mg PO qd x3 days; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[8-9 kg]

Dose: 187.5 mg/75 mg PO qd x3 days; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[10-19 kg]

Dose: 250 mg/100 mg PO qd x3 days; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[20-29 kg]

Dose: 500 mg/200 mg PO qd x3 days; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[30-39 kg]

Dose: 750 mg/300 mg PO qd x3 days; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

[>40 kg]

Dose: 1000 mg/400 mg PO qd x3 days; Info: repeat dose if vomiting occurs w/in 30min; give w/ food or milk; to avoid relapse in acute P. vivax or P. ovale infection, follow up tx w/ primaquine; refer to CDC guidelines

Renal dosing

[malaria prophylaxis]

CrCl <30: contraindicated

HD/PD: not defined

[malaria tx]

CrCl >30: no adjustment; CrCl <30: not defined, caution advised

HD/PD: not defined

Hepatic dosing

mild-mod impairment: no adjustment; severe impairment: not defined

SRC: NLM .