Mayzent Dosage
Generic name: siponimod
Drug class: Selective immunosuppressants
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 0.25 mg, 1 mg, 2 mg
Multiple sclerosis, relapsing forms
- [CYP2C9 genotype *1/*1 or *1/*2 or *2/*2]
- Dose: 2 mg PO qd; Start: 0.25 mg PO qd x2 days, then 0.5 mg PO qd x1 day, then 0.75 mg PO qd x1 day, then 1.25 mg PO qd x1 day, then 2 mg PO qd; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; restart titration if titration dose missed >24h or if maintenance tx interrupted >4 days; do not cut/crush/chew tab
- [CYP2C9 genotype *1/*3 or *2/*3]
- Dose: 1 mg PO qd; Start: 0.25 mg PO qd x2 days, then 0.5 mg PO qd x1 day, then 0.75 mg PO qd x1 day, then 1 mg PO qd; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; restart titration if titration dose missed >24h or if maintenance tx interrupted >4 days; do not cut/crush/chew tab
Renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
Hepatic dosing
- hepatic impairment: no adjustment; Info: caution advised if significant liver dz hx, monitor closely
SRC: NLM .