Mircera Dosage

Generic name: epoetin beta and methoxy polyethylene glycol
Drug class: Recombinant human erythropoietins

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ (pre-filled syringe): 30 mcg per 0.3 mL, 50 mcg per 0.3 mL, 75 mcg per 0.3 mL, 100 mcg per 0.3 mL, 120 mcg per 0.3 mL, 150 mcg per 0.3 mL, 200 mcg per 0.3 mL, 250 mcg per 0.3 mL, 360 mcg per 0.6 mL

Anemia, CKD-associated

[dialysis pts]

Dose: individualize dose SC/IV q2-4wk; Start: 0.6 mcg/kg/dose SC/IV q2wk for ESA-naive pts; Info: for pts w/ Hgb <10 g/dL; IV route preferred; use lowest dose to maintain Hgb sufficient to reduce RBC transfusion need; incr. dose 25% if Hgb response <1 g/dL/4wk, may incr. q4wk; do not incr. dose further if inadequate response by 12wk; decr. dose 25% if Hgb response >1 g/dL/2wk; decr. dose or interrupt tx if Hgb nearing or exceeds 11 g/dL; see pkg insert for conversion from other ESAs

[non-dialysis pts]

Dose: individualize dose SC/IV q2-4wk; Start: 0.6 mcg/kg/dose SC/IV q2wk for ESA-naive pts; Info: for pts w/ Hgb <10 g/dL and when rate of decline indicates RBC transfusion need; use lowest dose to maintain Hgb sufficient to reduce RBC transfusion need; incr. dose 25% if Hgb response <1 g/dL/4wk, may incr. q4wk; do not incr. dose further if inadequate response by 12wk; decr. dose 25% if Hgb response >1 g/dL/2wk; decr. dose or interrupt tx if Hgb >10 g/dL; see pkg insert for conversion from other ESAs

Renal dosing

renal impairment: no adjustment

HD/PD: no adjustment; no supplement; Info: IV route preferred for HD

Hepatic dosing

[no adjustment]

SRC: NLM .