Myalept Dosage
Generic name: metreleptin
Drug class: Miscellaneous metabolic agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ: 5 mg per mL
Restricted Distribution in US
Leptin deficiency
- [<40 kg]
- Dose: individualize dose SC qd; Start: 0.06 mg/kg/dose SC qd, then may adjust by 0.02 mg/kg/day; Max: 0.13 mg/kg/day; Info: for pts w/ congenital or acquired generalized lipodystrophy; see pkg insert for specific weight-based dose and volume recommendations; taper dose over 1wk to D/C if pancreatitis risk
- [>40 kg, female pts]
- Dose: individualize dose SC qd; Start: 5 mg SC qd, then may adjust by 1.25-2.5 mg/day; Max: 10 mg/day; Info: for pts w/ congenital or acquired generalized lipodystrophy; taper dose over 1wk to D/C if pancreatitis risk
- [>40 kg, male pts]
- Dose: individualize dose SC qd; Start: 2.5 mg SC qd, then may adjust by 1.25-2.5 mg/day; Max: 10 mg/day; Info: for pts w/ congenital or acquired generalized lipodystrophy; taper dose over 1wk to D/C if pancreatitis risk
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
Recommended Peds Dosing
- Dosage forms: INJ: 5 mg per mL
Restricted Distribution in US
Leptin deficiency
- [<40 kg]
- Dose: individualize dose SC qd; Start: 0.06 mg/kg/dose SC qd, then may adjust by 0.02 mg/kg/day; Max: 0.13 mg/kg/day; Info: for pts w/ congenital or acquired generalized lipodystrophy; see pkg insert for specific weight-based dose and volume recommendations; taper dose over 1wk to D/C if pancreatitis risk
- [>40 kg, female pts]
- Dose: individualize dose SC qd; Start: 5 mg SC qd, then may adjust by 1.25-2.5 mg/day; Max: 10 mg/day; Info: for pts w/ congenital or acquired generalized lipodystrophy; taper dose over 1wk to D/C if pancreatitis risk
- [>40 kg, male pts]
- Dose: individualize dose SC qd; Start: 2.5 mg SC qd, then may adjust by 1.25-2.5 mg/day; Max: 10 mg/day; Info: for pts w/ congenital or acquired generalized lipodystrophy; taper dose over 1wk to D/C if pancreatitis risk
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .