Myrbetriq Dosage

Generic name: mirabegron
Drug class: Urinary antispasmodics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  ER TAB: 25 mg, 50 mg

Overactive bladder

[monotherapy]

Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: do not cut/crush/chew tab

[combo tx]

Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: give w/ solifenacin; do not cut/crush/chew tab

Renal dosing

eGFR 15-29: max 25 mg/day; eGFR <15: avoid use

HD/PD: avoid use

Hepatic dosing

[adjust dose amount]

Child-Pugh Class B: max 25 mg/day; Child-Pugh Class C: avoid use

Recommended Peds Dosing

Dosage forms:  ER TAB: 25 mg, 50 mg; ER SUSP: 8 mg per mL

Special Note

[formulation clarification]

Info: mirabegron ER products not interchangeable; do not substitute on a mg to mg basis; reassess dose if switching between products

Detrusor overactivity, neurogenic

[ER suspension form, 3 yo and older, 11-21 kg]

Dose: 24-48 mg PO qd; Start: 24 mg PO qd, may incr. to 48 mg PO qd; Max: 48 mg /day; Info: give w/ food

[ER suspension form, 3 yo and older, 22-34 kg]

Dose: 32-64 mg PO qd; Start 32 mg PO qd, may incr. to 64 mg PO qd; Max: 64 mg/day; Info: give w/ food

[ER suspension form, 3 yo and older, >35 kg]

Dose: 48-80 mg PO qd; Start: 48 mg PO qd, may incr. to 80 mg PO qd after 4-8wk; Max: 80 mg/day; Info: give w/ food

[ER tablet form, 3 yo and older, >35 kg]

Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: give w/ food; do not cut/crush/chew tab

Renal dosing

[ER suspension form, 3 yo and older, 11-21 kg]

eGFR 15-29: max 24 mg/day; eGFR <15: avoid use

HD/PD: avoid use

[ER suspension form, 3 yo and older, 22-34 kg]

eGFR 15-29: max 32 mg/day; eGFR <15: avoid use

HD/PD: avoid use

[ER suspension form, 3 yo and older, >35 kg]

eGFR 15-29: max 48 mg/day; eGFR <15: avoid use

HD/PD: avoid use

[ER tablet form, 3 yo and older, >35 kg]

eGFR 15-29: max 25 mg/day; eGFR <15: avoid use

HD/PD: avoid use

Hepatic dosing

[ER suspension form, 3 yo and older, 11-21 kg]

Child-Pugh Class B: max 24 mg/day; Child-Pugh Class C: avoid use

[ER suspension form, 3 yo and older, 22-34 kg]

Child-Pugh Class B: max 32 mg/day; Child-Pugh Class C: avoid use

[ER suspension form, 3 yo and older, >35 kg]

Child-Pugh Class B: max 48 mg/day; Child-Pugh Class C: avoid use

[ER tablet form, 3 yo and older, >35 kg]

Child-Pugh Class B: max 25 mg/day; Child-Pugh Class C: avoid use

SRC: NLM .