Mysoline Dosage

Generic name: primidone
Drug class: Barbiturate anticonvulsants

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 50 mg, 250 mg

Seizure disorder

[250 mg PO tid-qid]

Start: 100-125 mg PO qhs x3 days, then 100-125 mg PO bid x3 days, then 100-125 mg PO tid x3 days, then 250 mg PO tid-qid; Max: 2 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

Essential tremor

[50-250 mg PO qhs]

Start: 12.5-25 mg PO qhs, incr. by 12.5-25 mg/day qwk; Max: 750 mg/day; Info: divide doses >250 mg/day; taper dose gradually to D/C

Renal dosing

[adjust dose frequency]

CrCl >50: give usual dose q12h; CrCl 10-50: give usual dose q12-24h; CrCl <10: give usual dose q24h; Info: adjust dose based on tx response and serum levels

HD: give usual dose q24h, on dialysis days admin. after dialysis; no supplement; PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised

Recommended Peds Dosing

Dosage forms:  TAB: 50 mg, 250 mg

Seizure disorder

[neonates]

Dose: 12-20 mg/kg/day PO divided bid-qid; Start: 15-20 mg/kg/dose PO x1; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

[<8 yo]

Dose: 10-25 mg/kg/day PO divided tid-qid; Start: 50 mg PO qhs x3 days, then 50 mg PO bid x3 days, then 100 mg PO bid x3 days; Max: 2 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

[8 yo and older]

Dose: 250 mg PO tid-qid; Start: 100-125 mg PO qhs x3 days, then 100-125 mg PO bid x3 days, then 100-125 mg PO tid x3 days, then 250 mg PO tid-qid; Max: 2 g/day; Info: adjust dose based on tx response and serum levels; taper dose gradually to D/C

Renal dosing

[adjust dose frequency]

CrCl >50: give usual dose q12h; CrCl 10-50: give usual dose q12-24h; CrCl <10: give usual dose q24h; Info: adjust dose based on tx response and serum levels

HD: give usual dose q24h, on dialysis days admin. after dialysis; no supplement; PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .